P-Glycoprotein and Its Role in Treatment Resistance

Co-treatment by docetaxel and vinblastine breaks down P-glycoprotein mediated chemo-resistance

Objective(s): Chemoresistance remains the main causes of treatment failure and mortality in cancer patients. There is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. Induction of drug efflux due to overexpression of                  P-glycoproteins is considered as an important leading cause of multidrug resistance...

Role of ABCB5 P-glycoprotein in Breast Cancer Multidrug Resistance

Rigol N, Frank NY, Margaryan A, Schatton T, Frank MH. Differential expression of ABCB5 multidrug resistance P-glycoprotein in human breast cancer cell lines. Proceedings of the Department of Defense Breast Cancer Research Program Meeting (Era of Hope), June 8-11, 2005, Philadelphia, PA. 2005:467 Abstract P667.

co-treatment by docetaxel and vinblastine breaks down p-glycoprotein mediated chemo-resistance

objective(s): chemoresistance remains the main causes of treatment failure and mortality in cancer patients. there is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. induction of drug efflux due to overexpression of                  p-glycoproteins is considered as an important leading cause of multidrug resis...

P-glycoprotein and multidrug resistance protein activities in relation to treatment outcome in acute myeloid leukemia.

Despite treatment with intensive chemotherapy, a considerable number of patients with acute myeloid leukemia (AML) die from their disease due to the occurrence of resistance. Overexpression of the transporter proteins P-glycoprotein (P-gp) and multidrug resistance protein (MRP) 1 has been identified as a major cause of cross-resistance to functionally and structurally unrelated drugs. In the pr...

Multidrug Resistance Protein (P-Glycoprotein; MDR1)